The mitochondrial death pathway and cardiac myocyte apoptosis

被引：538

作者：

Crow, MT

Mani, K

Nam, YJ

Kitsis, RN

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21224 USA

[2] Albert Einstein Coll Med, Cardiovasc Res Ctr, Dept Med, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Cardiovasc Res Ctr, Dept Cell Biol, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Ctr Canc, Bronx, NY 10461 USA

来源：

CIRCULATION RESEARCH | 2004年 / 95卷 / 10期

关键词：

apoptosis; necrosis; cell death; mitochondria; Bcl-2; caspase; death inducing signaling complex; apoptosome; ischemia; heart failure;

D O I：

10.1161/01.RES.0000148632.35500.d9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.

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页码：957 / 970

页数：14

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