Regional cerebral blood flow and vascular reserve in neuronal migration disorder assessed by Tc-99m hexamethylpropylene amineoxime SPECT with acetazolamide challenge

被引：0

作者：

Kojima, T

Mizumura, S

Kumita, SI

Nakajo, H

Kumazaki, T

Kitamura, T

Fukino, K

Teramoto, A

机构：

[1] Nippon Med Sch, Dept Neurosurg, Tokyo 113, Japan

[2] Nippon Med Sch, Dept Radiol, Tokyo 113, Japan

来源：

CLINICAL NUCLEAR MEDICINE | 2000年 / 25卷 / 09期

关键词：

acetazolamide; lissencephaly; neuronal migration disorder; SPECT;

D O I：

10.1097/00003072-200009000-00029

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 20-month-old boy had left hemiparesis and mental retardation. Magnetic resonance imaging revealed agyria-pachygyria in the right cerebral hemisphere, but magnetic resonance angiography showed no arterial stenosis or hypoplasia. Resting SPECT showed reduced Tc-99m hexamethylpropylene amineoxime accumulation in the affected cortex compared with the contralateral unaffected cortex, but during acetazolamide administration accumulation in the affected cortex was similar to that in the unaffected cortex. These findings suggest that the vasodilator function of the affected cortex was intact. This supports the contention that the low accumulation of cerebral blood flow tracer in migration disorder does not reflect impaired cerebral blood supply but rather reduced tissue activity.

引用

页码：749 / 750

页数：2