Distribution difference of colostrum-derived B and T cells subsets in gilts and sows

被引:17
作者
Forner, Ricardo [1 ]
Bombassaro, Gabrielly [2 ]
Bellaver, Franciana Volpato [2 ]
Maciag, Shaiana [3 ]
Fonseca, Francisco Noe [4 ]
Gava, Danielle [4 ]
Lopes, Leticia [4 ]
Marques, Mariana Groke [4 ]
Bastos, Ana Paula [1 ,4 ]
机构
[1] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
[2] Inst Fed Catarinense, Campus Concordia, Concordia, SC, Brazil
[3] Univ Estadual Ctr Oeste Parana, Campus CEDETEG, Guarapuava, PR, Brazil
[4] Embrapa Suinos & Aves, Concordia, SC, Brazil
来源
PLOS ONE | 2021年 / 16卷 / 05期
关键词
PERIPHERAL-BLOOD; IMMUNOGLOBULIN-G; MAMMARY-GLAND; PORCINE COLOSTRUM; MEDIATED-IMMUNITY; BIRTH-WEIGHT; MILK; EXPRESSION; LYMPHOCYTES; PIGLETS;
D O I
10.1371/journal.pone.0249366
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Piglets are highly vulnerable to infections, but colostrum provides them with some protection. The function of colostrum components is unknown, as is if the amount and subsets of leukocytes in colostrum differ between gilts and sows. This study serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows (parities orders 3-4) from a commercial herd were examined. Flow cytometry is a useful tool to identify and quantify leukocyte subsets in sow colostrum. Overall, there were no (p >= 0.05) parity differences in total macrophages, granulocytes, and T and B cells. However, the sows' colostrum presented significantly higher (p <= 0.05) T lymphocyte subsets than gilts, such as central memory CD4(+)T cells, effector memory CD4(+)T cells, and central memory CD8(+)T cells. Among B-lymphocytes, percentages of SWC7(+)CD5(+) cells were significantly higher in sow colostrum than in that of gilts. As expected, IgG concentrations were significantly higher in sows than in gilts. Colostrum from sows had significantly greater mitogenic activity than colostrum from gilts and this fact can be associated with the potential to accelerate the maturation of a newborn's gastrointestinal tract. Our findings suggest that parity order may be one among other factors influencing the cell population and, consequently, the immune adaptive response in piglets that induces neutralizing antibodies and cellular immune responses to antigens.
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页数:18
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