Defining Adult Stem Cells by Function, not by Phenotype

被引:153
作者
Clevers, Hans [1 ,2 ]
Watt, Fiona M. [3 ]
机构
[1] Royal Netherlands Acad Arts & Sci KNAW, Princess Maxima Ctr Pediat Oncol, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands
[3] Kings Coll London, Ctr Stem Cells & Regenerat Med, London SE1 9RT, England
来源
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 | 2018年 / 87卷
关键词
adult stem cell; asymmetric division; quiescence; neutral competition; self-renewal; tissue maintenance; LABEL-RETAINING CELLS; MAMMARY-GLAND; INTERFOLLICULAR EPIDERMIS; SECRETORY PRECURSORS; INTESTINAL CRYPT; PROGENITOR CELLS; ALVEOLAR CELLS; BONE MARROW; IN-VIVO; LIVER;
D O I
10.1146/annurev-biochem-062917-012341
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the transplantable HSC. The HSC paradigm has served as a stereotypic template in stem cell biology, yet the search for rare, hardwired professional stem cells has remained futile in most other tissues. In a more open approach, the focus on the search for stem cells as a physical entity may need to be replaced by the search for stem cell function, operationally defined as the ability of an organ to replace lost cells. The nature of such a cell may be different under steady state conditions and during tissue repair. We discuss emerging examples including the renewal strategies of the skin, gut epithelium, liver, lung, and mammary gland in comparison with those of the hematopoietic system. While certain key housekeeping and developmental signaling pathways are shared between different stem cell systems, there may be no general, deeper principles underlying the renewal mechanisms of the various individual tissues.
引用
收藏
页码:1015 / 1027
页数:13
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