Iron homeostasis: An anthropocentric perspective

被引：141

作者：

Coffey, Richard

Ganz, Tomas ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2017年 / 292卷 / 31期

基金：

美国国家卫生研究院;

关键词：

erythropoiesis; hepatocyte; infection; inflammation; iron metabolism; TRANSFERRIN-BOUND IRON; METAL-ION TRANSPORTER; MORPHOGENETIC PROTEIN 6; HEPCIDIN EXPRESSION; HEREDITARY HEMOCHROMATOSIS; MOUSE MODEL; JUVENILE HEMOCHROMATOSIS; MESSENGER-RNA; ERYTHROFERRONE CONTRIBUTES; FUNCTIONAL-PROPERTIES;

D O I：

10.1074/jbc.R117.781823

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels. Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin. Hepcidin is feedback-regulated by iron status and strongly modulated by inflammation and erythropoietic demand. This review highlights recent advances that have changed our understanding of iron metabolism and its regulation.

引用

收藏

页码：12727 / 12734

页数：8

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共 100 条

[91] Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats [J].

Walter, PB ;

Knutson, MD ;

Paler-Martinez, A ;

Lee, S ;

Xu, Y ;

Viteri, FE ;

Ames, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2264-2269

[92] Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice [J].

Wang, Chia-Yu ;

Knutson, Mitchell D. .

HEPATOLOGY, 2013, 58 (02) :788-798

[93] ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading [J].

Wang, Chia-Yu ;

Jenkitkasemwong, Supak ;

Duarte, Stephanie ;

Sparkman, Brian K. ;

Shawki, Ali ;

Mackenzie, Bryan ;

Knutson, Mitchell D. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (41) :34032-34043

[94] HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis [J].

White, Carine ;

Yuan, Xiaojing ;

Schmidt, Paul J. ;

Bresciani, Erica ;

Samuel, Tamika K. ;

Campagna, Dean ;

Hall, Caitlin ;

Bishop, Kevin ;

Calicchio, Monica L. ;

Lapierre, Ariane ;

Ward, Diane M. ;

Liu, Paul ;

Fleming, Mark D. ;

Hamza, Iqbal .

CELL METABOLISM, 2013, 17 (02) :261-270

[95] HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression [J].

Wu, Xing-gang ;

Wang, Yang ;

Wu, Qian ;

Cheng, Wai-Hang ;

Liu, Wenjing ;

Zhao, Yueshui ;

Mayeur, Claire ;

Schmidt, Paul J. ;

Yu, Paul B. ;

Wang, Fudi ;

Xia, Yin .

BLOOD, 2014, 124 (08) :1335-1343

[96] Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart [J].

Xu, Wenjing ;

Barrientos, Tomasa ;

Mao, Lan ;

Rockman, Howard A. ;

Sauve, Anthony A. ;

Andrews, Nancy C. .

CELL REPORTS, 2015, 13 (03) :533-545

[97] Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2 [J].

Yanatori, Izumi ;

Richardson, Des R. ;

Imada, Kiyoshi ;

Kishi, Fumio .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (33) :17303-17318

[98] Chaperone protein involved in transmembrane transport of iron [J].

Yanatori, Izumi ;

Yasui, Yumiko ;

Tabuchi, Mitsuaki ;

Kishi, Fumio .

BIOCHEMICAL JOURNAL, 2014, 462 :25-37

[99] Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein [J].

Zhang, An-Sheng ;

Anderson, Sheila A. ;

Wang, Jiaohong ;

Yang, Fan ;

DeMaster, Kristina ;

Ahmed, Riffat ;

Nizzi, Christopher P. ;

Eisenstein, Richard S. ;

Tsukamoto, Hidekazu ;

Enns, Caroline A. .

BLOOD, 2011, 117 (05) :1687-1699

[100] Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype [J].

Zumerle, Sara ;

Mathieu, Jacques R. R. ;

Delga, Stephanie ;

Heinis, Mylene ;

Viatte, Lydie ;

Vaulont, Sophie ;

Peyssonnaux, Carole .

BLOOD, 2014, 123 (23) :3646-3650

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