Iron homeostasis: An anthropocentric perspective

被引：141
作者：
Coffey, Richard
Ganz, Tomas [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2017年 / 292卷 / 31期
基金：
美国国家卫生研究院;
关键词：
erythropoiesis; hepatocyte; infection; inflammation; iron metabolism; TRANSFERRIN-BOUND IRON; METAL-ION TRANSPORTER; MORPHOGENETIC PROTEIN 6; HEPCIDIN EXPRESSION; HEREDITARY HEMOCHROMATOSIS; MOUSE MODEL; JUVENILE HEMOCHROMATOSIS; MESSENGER-RNA; ERYTHROFERRONE CONTRIBUTES; FUNCTIONAL-PROPERTIES;
D O I：
10.1074/jbc.R117.781823
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels. Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin. Hepcidin is feedback-regulated by iron status and strongly modulated by inflammation and erythropoietic demand. This review highlights recent advances that have changed our understanding of iron metabolism and its regulation.
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收藏
页码：12727 / 12734
页数：8
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