Solubility and thermodynamic function of lornoxicam in (PEG-400+water) mixtures at different temperatures

被引：7
|
作者：
Shakeel, Faiyaz [1 ,2 ]
Haq, Nazrul [1 ,2 ]
Alanazi, Fars K. [2 ]
Alsarra, Ibrahim A. [1 ,2 ]
机构：
[1] King Saud Univ, Coll Sci, Ctr Excellence Biotechnol Res, POB 2460, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, Kayyali Chair Pharmaceut Ind, POB 2457, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 219卷
关键词：
Cosolvent mixture; Lornoxicam; PEG-400; Solubility; Thermodynamics; POLYETHYLENE-GLYCOLS; 200; MAGNESIUM-DL-ASPARTATE; MIXED-SOLVENT SYSTEMS; P-TOLUIC ACID; COSOLVENT MIXTURES; TERNARY SOLVENTS; DOUBLE-BLIND; 298.2; K; WATER; BINARY;
D O I：
10.1016/j.molliq.2016.03.058
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present study was undertaken to determine the solubility and thermodynamic function of a poorly soluble drug lornoxicam (LNX) in various [polyethylene glycol-400 (PEG-400) + water] mixtures at five different temperatures from T = (298.15 to 323.15) K and atmospheric pressure. The measured solubilities of LNX were correlated with three different mathematical models which showed good correlation of experimental solubilities of LNX with calculated ones. The mole fraction solubility of LNX was found to be highest in pure PEG-400 (1.71 x 10(-2) at T = 323.15 K) and lowest in pure water (2.90 x 10(-6) at T = 298.15 K) at all five different temperatures investigated. Thermodynamic function of LNX in different (PEG-400 + water) mixtures was recorded as an endothermic, spontaneous and entropy driven. These results indicated that PEG-400 could be utilized as a good solvent for solubilization and stabilization of LNX in an aqueous media. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：439 / 443
页数：5
相关论文
共 50 条
  • [21] Solubility and Thermodynamic Analysis of Isotretinoin in Different (DMSO plus Water) Mixtures
    Shakeel, Faiyaz
    Haq, Nazrul
    Alshehri, Sultan
    Alenazi, Miteb
    Alwhaibi, Abdulrahman
    Alsarra, Ibrahim A.
    MOLECULES, 2023, 28 (20):
  • [22] Solubility of mesalazine in ethylene glycol plus water mixtures at different temperatures
    Sheikhi-Sovari, Atefeh
    Jouyban, Abolghasem
    Martinez, Fleming
    Hemmati, Salar
    Rahimpour, Elaheh
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 323
  • [23] Solubility of mesalazine in {1-propanol/water} mixtures at different temperatures
    Agha, Elnaz Mazaher Haji
    Barzegar-Jalali, Mohammad
    Adibkia, Khosro
    Hemmati, Salar
    Kuentz, Martin
    Martinez, Fleming
    Jouyban, Abolghasem
    JOURNAL OF MOLECULAR LIQUIDS, 2020, 301
  • [24] Solubility of Ketoconazole in Ethylene Glycol plus Water Mixtures at Different Temperatures
    Rezaei, Homa
    Jouyban, Abolghasem
    Martinez, Fleming
    Rahimpour, Elaheh
    MOSCOW UNIVERSITY CHEMISTRY BULLETIN, 2023, 78 (03) : 145 - 149
  • [25] Solubility and thermodynamics of vanillin in Carbitol-water mixtures at different temperatures
    Shakeel, Faiyaz
    Haq, Nazrul
    Siddiqui, Nasir A.
    Alanazi, Fars K.
    Alsarra, Ibrahim A.
    LWT-FOOD SCIENCE AND TECHNOLOGY, 2015, 64 (02) : 1278 - 1282
  • [26] Comments on "Solubility and thermodynamic function of a new anticancer drug ibrutinib in {2-(2-ethoxyethoxy)ethanol plus water} mixtures at different temperatures"
    Martinez, Fleming
    Jouyban, Abolghasem
    Acree, William E., Jr.
    JOURNAL OF CHEMICAL THERMODYNAMICS, 2016, 95 : 180 - 182
  • [27] Solubility and thermodynamic behavior of vanillin in propane-1, 2-diol + water cosolvent mixtures at different temperatures
    Shakeel, Faiyaz
    Haq, Nazrul
    Siddiqui, Nasir A.
    Alanazi, Fars K.
    Alsarra, Ibrahim A.
    FOOD CHEMISTRY, 2015, 188 : 57 - 61
  • [28] Comments on "Solubility and thermodynamic behavior of vanillin in propane-1,2-diol + water cosolvent mixtures at different temperatures"
    Jouyban, Abolghasem
    Acree, William E., Jr.
    FOOD CHEMISTRY, 2016, 192 : 1049 - 1050
  • [29] Solubility and thermodynamic properties of mesalazine in {2-propanol + water} mixtures at various temperatures
    Agha, Elnaz Mazaher Haji
    Barzegar-Jalali, Mohammad
    Adibkia, Khosro
    Hemmati, Salar
    Martinez, Fleming
    Jouyban, Abolghasem
    JOURNAL OF MOLECULAR LIQUIDS, 2020, 301 (301)
  • [30] THERMODYNAMIC PROPERTIES OF HYDROCHLORIC ACID IN DIMETHYLFORMAMIDE WATER MIXTURES AT DIFFERENT TEMPERATURES
    ROY, RN
    VERNON, W
    BOTHWELL, AL
    JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC, 1971, (12): : 2320 - &
12345