Solubility and thermodynamic function of lornoxicam in (PEG-400+water) mixtures at different temperatures

被引：7
|
作者：
Shakeel, Faiyaz [1 ,2 ]
Haq, Nazrul [1 ,2 ]
Alanazi, Fars K. [2 ]
Alsarra, Ibrahim A. [1 ,2 ]
机构：
[1] King Saud Univ, Coll Sci, Ctr Excellence Biotechnol Res, POB 2460, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, Kayyali Chair Pharmaceut Ind, POB 2457, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 219卷
关键词：
Cosolvent mixture; Lornoxicam; PEG-400; Solubility; Thermodynamics; POLYETHYLENE-GLYCOLS; 200; MAGNESIUM-DL-ASPARTATE; MIXED-SOLVENT SYSTEMS; P-TOLUIC ACID; COSOLVENT MIXTURES; TERNARY SOLVENTS; DOUBLE-BLIND; 298.2; K; WATER; BINARY;
D O I：
10.1016/j.molliq.2016.03.058
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present study was undertaken to determine the solubility and thermodynamic function of a poorly soluble drug lornoxicam (LNX) in various [polyethylene glycol-400 (PEG-400) + water] mixtures at five different temperatures from T = (298.15 to 323.15) K and atmospheric pressure. The measured solubilities of LNX were correlated with three different mathematical models which showed good correlation of experimental solubilities of LNX with calculated ones. The mole fraction solubility of LNX was found to be highest in pure PEG-400 (1.71 x 10(-2) at T = 323.15 K) and lowest in pure water (2.90 x 10(-6) at T = 298.15 K) at all five different temperatures investigated. Thermodynamic function of LNX in different (PEG-400 + water) mixtures was recorded as an endothermic, spontaneous and entropy driven. These results indicated that PEG-400 could be utilized as a good solvent for solubilization and stabilization of LNX in an aqueous media. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：439 / 443
页数：5
相关论文
共 50 条
  • [1] Thermodynamic solubility and solvation behavior of ferulic acid in different (PEG-400+water) binary solvent mixtures
    Shakeel, Faiyaz
    Haq, Nazrul
    Siddiqui, Nasir A.
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2019, 45 (09) : 1468 - 1476
  • [2] Solubility and thermodynamics of tenoxicam in (PEG-400+water) binary solvent systems at different temperatures
    Shakeel, Faiyaz
    Haq, Nazrul
    Alanazi, Fars K.
    Alsarra, Ibrahim A.
    JOURNAL OF MOLECULAR LIQUIDS, 2016, 213 : 221 - 227
  • [3] Solubility determination and solution thermodynamics of olmesartan medoxomil in (PEG-400+water) cosolvent mixtures
    Al-Shdefat, Ramadan
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2020, 46 (12) : 2098 - 2104
  • [4] Dissolution thermodynamics and solubility of silymarin in PEG 400-water mixtures at different temperatures
    Shakeel, Faiyaz
    Anwer, Md Khalid
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2015, 41 (11) : 1819 - 1823
  • [5] Solubility data, Hansen solubility parameters and thermodynamic behavior of pterostilbene in some pure solvents and different (PEG-400+water) cosolvent compositions
    Alqarni, Mohammed H.
    Haq, Nazrul
    Alam, Prawez
    Abdel-Kader, Maged S.
    Foudah, Ahmed, I
    Shakeel, Faiyaz
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 331
  • [6] Solubility and thermodynamic function of bergenin in different (DMSO plus water) mixtures at different temperatures
    Shakeel, Faiyaz
    Mothana, Ramzi A.
    Haq, Nazrul
    Siddiqui, Nasir A.
    Al-Oqail, Mai M.
    Al-Rehaily, Adnan J.
    JOURNAL OF MOLECULAR LIQUIDS, 2016, 220 : 823 - 828
  • [7] Solubility and Thermodynamic Properties of Febuxostat in Various (PEG 400+Water) Mixtures
    Alghaith, Adel F.
    Mahdi, Wael A.
    Haq, Nazrul
    Alshehri, Sultan
    Shakeel, Faiyaz
    MATERIALS, 2022, 15 (20)
  • [8] Solubility prediction of indomethacin in PEG 400+water mixtures at various temperatures
    Shakeel, Faiyaz
    Alanazi, Fars K.
    Alsarra, Ibrahim A.
    Haq, Nazrul
    JOURNAL OF MOLECULAR LIQUIDS, 2013, 188 : 28 - 32
  • [9] Solubility of mesalazine in polyethylene glycol 400+water mixtures at different temperatures
    Moradi, Milad
    Rahimpour, Elaheh
    Hemmati, Salar
    Martinez, Fleming
    Barzegar-Jalali, Mohammad
    Jouyban, Abolghasem
    JOURNAL OF MOLECULAR LIQUIDS, 2020, 314
  • [10] Solubility and thermodynamic analysis of aceclofenac in different {Carbitol plus water} mixtures at various temperatures
    Shakeel, Faiyaz
    Al-Shdefat, Ramadan
    Altamimi, Mohammad A.
    Ahmad, Usama
    BMC CHEMISTRY, 2024, 18 (01)
12345