Solubility and thermodynamic function of lornoxicam in (PEG-400+water) mixtures at different temperatures

被引：7
作者：
Shakeel, Faiyaz [1 ,2 ]
Haq, Nazrul [1 ,2 ]
Alanazi, Fars K. [2 ]
Alsarra, Ibrahim A. [1 ,2 ]
机构：
[1] King Saud Univ, Coll Sci, Ctr Excellence Biotechnol Res, POB 2460, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, Kayyali Chair Pharmaceut Ind, POB 2457, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 219卷
关键词：
Cosolvent mixture; Lornoxicam; PEG-400; Solubility; Thermodynamics; POLYETHYLENE-GLYCOLS; 200; MAGNESIUM-DL-ASPARTATE; MIXED-SOLVENT SYSTEMS; P-TOLUIC ACID; COSOLVENT MIXTURES; TERNARY SOLVENTS; DOUBLE-BLIND; 298.2; K; WATER; BINARY;
D O I：
10.1016/j.molliq.2016.03.058
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present study was undertaken to determine the solubility and thermodynamic function of a poorly soluble drug lornoxicam (LNX) in various [polyethylene glycol-400 (PEG-400) + water] mixtures at five different temperatures from T = (298.15 to 323.15) K and atmospheric pressure. The measured solubilities of LNX were correlated with three different mathematical models which showed good correlation of experimental solubilities of LNX with calculated ones. The mole fraction solubility of LNX was found to be highest in pure PEG-400 (1.71 x 10(-2) at T = 323.15 K) and lowest in pure water (2.90 x 10(-6) at T = 298.15 K) at all five different temperatures investigated. Thermodynamic function of LNX in different (PEG-400 + water) mixtures was recorded as an endothermic, spontaneous and entropy driven. These results indicated that PEG-400 could be utilized as a good solvent for solubilization and stabilization of LNX in an aqueous media. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：439 / 443
页数：5
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