Tamoxifen promotes apoptosis and inhibits invasion in estrogen-positive breast cancer MCF-7 cells

被引：28

作者：

Li, Wei ^{[1
]}

Shi, Xingpeng ^{[1
]}

Xu, Yan ^{[2
]}

Wan, Jianmei ^{[3
]}

Wei, Shaohua ^{[1
]}

Zhu, Ran ^{[3
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Dept Gen Surg, 181 Sanxiang Rd, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Gen Surg, Suzhou 215123, Jiangsu, Peoples R China

[3] Soochow Univ, Collaborat Innovat Ctr Radiat Med,Med Coll, Jiangsu Higher Educ Inst,Sch Radiat Med & Protect, Jiangsu Prov Key Lab Radiat Med & Protect, 199 Renai Rd,Suzhou Ind Pk, Suzhou 215123, Jiangsu, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2017年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

tamoxifen; estrogen-positive; mitochondrial membrane potential; reactive oxygen species; MECHANISMS; ACTIVATION; PROGRESSION; THERAPY; PROLIFERATION; ANTIESTROGENS; TRANSCRIPTION; RESISTANCE; INDUCTION; GENE;

D O I：

10.3892/mmr.2017.6603

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tamoxifen (TAM) is the earliest non-steroidal antiestrogen drug, which has been widely used in endocrine therapy targeting breast cancer. The aim of the present study was to investigate the effect of TAM on the proliferation, apoptosis, migration and invasion of the estrogen-positive (ER+) breast cancer cell line MCF-7 in vitro, and elucidate its mechanisms. It was demonstrated that TAM suppressed proliferation, migration and invasion, and induced apoptosis in MCF-7 cells. Further investigation revealed that the mitochondrial membrane potential and the amount of ATP were significantly decreased following the treatment of MCF-7 cells with TAM. Mitochondria are an important source of reactive oxygen species (ROS) and they are also the target of ROS as well. In the present study, TAM promoted the formation of ROS in MCF-7 cells. In conclusion, these results reveal the underlying mechanism by which TAM induces ER+ breast cancer cell apoptosis and inhibits invasion, thereby supporting the use of TAM in breast cancer treatment.

引用

页码：478 / 484

页数：7

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