Altered first-trimester screening markers after IVF/ICSI: no relationship with small-for-gestational-age and number of embryos transferred

被引：20

作者：

Bender, F. ^{[2
]}

Hecken, J. ^{[1
]}

Reinsberg, J. ^{[2
]}

Berg, C. ^{[1
]}

van der Ven, H. ^{[2
]}

Gembruch, U. ^{[1
]}

Geipel, A. ^{[1
]}

机构：

[1] Univ Bonn, Dept Obstet & Prenatal Med, D-53105 Bonn, Germany

[2] Univ Hosp, Dept Endocrinol & Reprod Med, Bonn, Germany

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2010年 / 20卷 / 04期

关键词：

beta-human chorionic gonadotrophin (beta HCG); first-trimester screening; ICSI; IVF; pregnancy-associated plasma protein A (PAPP-A); small-for-gestational-age; HUMAN CHORIONIC-GONADOTROPIN; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE TECHNOLOGY; INTRACYTOPLASMIC SPERM INJECTION; PLASMA-PROTEIN-A; FREE-BETA-HCG; MATERNAL SERUM BIOCHEMISTRY; FREE FETAL DNA; DOWNS-SYNDROME; PAPP-A;

D O I：

10.1016/j.rbmo.2009.12.025

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

First-trimester serum markers in 110 in-vitro fertilization (IVF) and 331 intracytoplasmatic sperm injection (ICSI) pregnancies were compared with 1431 pregnancies with spontaneous conception. Alterations of serum markers were evaluated with respect to small-for-gestational-age (SGA) growth and number of embryos transferred. For pregnancy-associated plasma protein A (PAPP-A), significantly lower concentrations were observed in IVF and ICSI pregnancies compared with controls (0.86 and 0.9 versus 1.06; P < 0.001). Free beta-human chorionic gonadotrophin (beta HCG) values were significantly higher in the IVF/ICSI groups than in controls (1.1 and 1.1 versus 0.94; P< 0.005). IVF and ICSI pregnancies showed higher rates of SGA (10.0% and 8.2%) compared with natural conception (4.6%), but differences in PAPP-A concentrations remained significant (P < 0.005) after the exclusion of SGA pregnancies. No relationship between serum values and the transfer of one, two or three embryos was observed. Centre-specific corrections may be needed to adjust screening parameters for assisted reproductive technology. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：516 / 522

页数：7

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