MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas

被引：29

作者：

Abe, Hideaki ^{[1
]}

Natsumeda, Manabu ^{[1
]}

Kanemaru, Yu ^{[1
]}

Watanabe, Jun ^{[1
]}

Tsukamoto, Yoshihiro ^{[1
]}

Okada, Masayasu ^{[1
]}

Yoshimura, Junichi ^{[1
]}

Oishi, Makoto ^{[1
]}

Fujii, Yukihiko ^{[1
]}

机构：

[1] Niigata Univ, Brain Res Inst, Dept Neurosurg, Niigata, Niigata, Japan

来源：

NEUROLOGIA MEDICO-CHIRURGICA | 2018年 / 58卷 / 07期

关键词：

MGMT; diffuse midline gliomas; Histone H3 mutation; resistance; epigenetics; INTRINSIC PONTINE GLIOMA; PEDIATRIC HIGH-GRADE; ADP-RIBOSE POLYMERASE; BRAIN-STEM; THERAPEUTIC TARGETS; K27M MUTATIONS; GLIOBLASTOMA; TUMORS; INHIBITOR; SUBGROUPS;

D O I：

10.2176/nmc.ra.2018-0044

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O-6-methylguanine-DNA methyltransferase (MGMT) promoter frequently lacks methylation in DMGs. This review compares the epigenetic changes brought about by histone mutations to those by isocitrate dehydrogenase-mutant gliomas, which frequently have methylated MGMT promoters and are known to be sensitive to temozolomide.

引用

页码：290 / 295

页数：6

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