Chemical composition, cytotoxic and antioxidant activity of the leaf essential oil of Photinia serrulata

The leaf essential oil of Photinia serrulata was obtained by hydrodistillation and analyzed by GC and GC-MS. Seventy-one components were identified in the essential oil and the main components of the oil were 10-epi-gamma-eudesmol (12.72%), pinene (6.85%), sabinene (5.93%), a-humulene (5.87%) and alpha-thujene (5.47%). The in vitro cytotoxicity of the oil on human cancer cell lines Hela, A-549 and Bel-7402 was examined. The oil was found to be very active against all the three human tumor cell lines tested with low IC50 of 0.0427 mu l/ml (Hela), 0.0219 mu l/ml (A-549) and 0.0301 mu l/ml (Bel-7402). The oil was also found to possess antioxidant activity as demonstrated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical method. (c) 2006 Elsevier Ltd. All rights reserved.