A regioselective approach to 5-substituted-3-amino-1,2,4-triazines

被引：20

作者：

Limanto, J ^{[1
]}

Desmond, RA ^{[1
]}

Gauthier, DR ^{[1
]}

Devine, PN ^{[1
]}

Reamer, RA ^{[1
]}

Volante, RP ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 13期

关键词：

D O I：

10.1021/ol034602+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic displacement of readily available alpha,alpha-dibromoketones with excess morpholine gave the corresponding ketoaminals, which upon condensation with aminoguanidine in MeOH in the presence of AcOH afforded 5-substituted-3-amino-1,2,4-triazines in >95% regioselectivity and 45-76% isolated yield.

引用

页码：2271 / 2274

页数：4

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