The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

被引:252
作者
Su, Tsung-Ping [1 ]
Su, Tzu-Chieh [1 ]
Nakamura, Yoki [1 ]
Tsai, Shang-Yi [1 ]
机构
[1] NIDA, Cellular Pathobiol Sect, Integrat Neurosci Res Branch, Intramural Res Program,NIH,US Dept HHS, Baltimore, MD 21224 USA
关键词
AMYOTROPHIC-LATERAL-SCLEROSIS; ENDOPLASMIC-RETICULUM MEMBRANE; MECHANICAL ALLODYNIA; OPIOID ANALGESIA; MOUSE MODEL; P38; MAPK; NEUROPATHIC PAIN; AGONIST PRE-084; INFARCT VOLUME; BINDING;
D O I
10.1016/j.tips.2016.01.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM), an interface between ER and mitochondria. In addition to being able to translocate to the plasma membrane (PM) to interact with ion channels and other receptors, Sig-1R also occurs at the nuclear envelope, where it recruits chromatin-remodeling factors to affect the transcription of genes. Sig-1Rs have also been reported to interact with other membranous or soluble proteins at other loci, including the cytosol, and to be involved in several central nervous system (CNS) diseases. Here, we propose that Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in living systems.
引用
收藏
页码:262 / 278
页数:17
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