Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension in Greece: Data from the Hellenic Pulmonary Hypertension Registry

被引：6

作者：

Karyofyllis, Panagiotis ^{[1
]}

Demerouti, Eftychia ^{[1
]}

Giannakoulas, George ^{[2
]}

Anthi, Anastasia ^{[3
]}

Arvanitaki, Alexandra ^{[2
]}

Athanassopoulos, George ^{[1
]}

Feloukidis, Christos ^{[2
]}

Iakovou, Ioannis ^{[1
]}

Kostelidou, Theodora ^{[1
]}

Mitrouska, Ioanna ^{[4
]}

Mouratoglou, Sophia-Anastasia ^{[2
]}

Orfanos, Stylianos E. ^{[3
]}

Pappas, Christos ^{[5
]}

Pitsiou, Georgia ^{[6
]}

Tsetika, Eleftheria-Garyfallia ^{[1
]}

Tsiapras, Dimitrios ^{[1
]}

Voudris, Vassilios ^{[1
]}

Manginas, Athanassios ^{[7
]}

机构：

[1] Onassis Cardiac Surg Ctr, Cardiol Dept, Athens 17674, Greece

[2] Aristotle Univ Thessaloniki, Ahepa Univ Hosp, Cardiol Dept, Thessaloniki 54621, Greece

[3] Natl & Kapodistrian Univ Athens, Pulm Hypertens Clin Evaggelismos Gen Hosp, Dept Crit Care 1, Med Sch, Athens 10676, Greece

[4] Univ Hosp Heraklion, Dept Intens Care Med, Iraklion 71110, Greece

[5] Attikon Univ Gen Hosp, Multidisciplinary Pulm Hypertens Ctr, Athens 12461, Greece

[6] G Papanikolaou Hosp, Resp Failure Unit, Thessaloniki 57010, Greece

[7] Mediterraneo Hosp, Cardiol Dept, Athens 16675, Greece

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 08期

关键词：

chronic thromboembolic pulmonary hypertension; balloon pulmonary angioplasty; pulmonary hypertension; registry; ENDARTERECTOMY;

D O I：

10.3390/jcm11082211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Balloon pulmonary angioplasty (BPA) is a novel and promising treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are ineligible for pulmonary endarterectomy (PEA) and for those with persistent or recurrent pulmonary hypertension after PEA. We present the results of BPA procedures in CTEPH patients included in the Greek Pulmonary Hypertension Registry, evaluating the real-life efficacy and safety. We analyzed data from 180 BPA procedures (2-17/patient, mean 8 +/- 4/patient, 1248 dilated vessels, 0-18/session). Significant improvements were observed in mean pulmonary arterial pressure (a reduction by 44%, p < 0.001), pulmonary vascular resistance (reduction by 60%, p < 0.001), and NT-proBNP (decrease by >70%, p: 0.003), while cardiac index improved modestly (9% increase, p = 0.143). We had 37 BPA-related non-fatal complications (20.6% in all interventions), predominantly including hemoptysis. Overall survival was 91%, 75% and 62% at 3, 4 and 5 years, respectively. Therefore, BPA may be a promising therapeutic option in patients with CTEPH in Greece.

引用

页数：14

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