Differences in cognitive ability and hippocampal volume between Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups, and their correlation

被引：15

作者：

Choi, Mi-Hyun ^{[1
]}

Kim, Hyung-Sik ^{[1
]}

Gim, Seon-Young ^{[1
]}

Kim, Woo-Ram ^{[1
]}

Mun, Kyung-Ryul ^{[1
]}

Tack, Gye-Rae ^{[1
]}

Lee, Bongsoo ^{[2
]}

Choi, Young Chil ^{[3
]}

Kim, Hyun-Jun ^{[4
]}

Hong, Seung Hwa ^{[5
]}

Lim, Dae-Woon ^{[6
]}

Chung, Soon-Cheol ^{[1
]}

机构：

[1] Konkuk Univ, Coll Biomed & Hlth Sci, Res Inst Biomed Engn, Dept Biomed Engn, Chungju, South Korea

[2] Chung Ang Univ, Sch Energy Syst Engn, Seoul 156756, South Korea

[3] Konkuk Univ, Sch Med, Dept Radiol, Chungju, South Korea

[4] Konkuk Univ, Dept Obstet & Gynecol, Chungju, South Korea

[5] Chungbuk Natl Univ Hosp, Dept Obstet & Gynecol, Cheongju, South Korea

[6] Dongguk Univ, Dept Informat & Commun Engn, Seoul, South Korea

来源：

NEUROSCIENCE LETTERS | 2016年 / 620卷

关键词：

Cognitive ability; Hippocampal volume; Alzheimer disease; Amnestic mild cognitive impairment; Boston naming test; PERFORMANCES; BIOMARKERS; ATROPHY; MRI;

D O I：

10.1016/j.neulet.2016.03.044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The study investigated differences in cognitive ability and hippocampal volume between groups of patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), and healthy control (HC) subjects, and explored the relationship between cognitive ability and hippocampal volume. Among the sub-tests of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), the Boston naming test score decreased in the order HC, aMCI, and AD. The hippocampal volumes of subjects with AD and aMCI were relatively smaller than those of HC individuals. There were strongly positive correlations between hippocampal volume and the scores for the Boston naming test. Discriminant analysis identified the Boston naming test as having the highest level of discrimination among the variables used to differentiate the three groups (89.9%). In conclusion, the Boston naming test accurately differentiated the three groups and was correlated with hippocampal volume. These results will be helpful for choosing an accurate and economically feasible test method that efficiently differentiates the three groups. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：115 / 120

页数：6

共 19 条

[1] 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease [J].