Opinion - Bias as a threat to the validity of cancer molecular-marker research

被引：362
作者：
Ransohoff, DF
机构：
[1] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
[3] NCI, Div Canc Prevent, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 02期
关键词：
D O I：
10.1038/nrc1550
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Claims that molecular markers can accurately diagnose cancer have recently been disputed; some prominent results have not been reproduced and bias has been proposed to explain the original observations. As new '-omics' fields are explored to assess molecular markers for cancer, bias will increasingly be recognized as the most important 'threat to validity' that must be addressed in the design, conduct and interpretation of such research.
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收藏
页码：142 / 149
页数：8
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