Thrombotic Microangiopathy in Systemic Lupus Erythematosus: Efficacy of Eculizumab

被引：73

作者：

El-Husseini, Amr ^{[1
,2
]}

Hannan, Schot ^{[1
]}

Awad, Ahmed ^{[1
]}

Jennings, Stuart ^{[1
]}

Cornea, Virgilius ^{[3
]}

Sawaya, B. Peter ^{[1
]}

机构：

[1] Univ Kentucky, Div Nephrol, Lexington, KY 40536 USA

[2] Mansoura Univ, Mansoura, Egypt

[3] Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2015年 / 65卷 / 01期

关键词：

Thrombotic microangiopathy (TMA); systemic lupus erythematosus (SLE); eculizumab; kidney biopsy; acute kidney injury (AKI); proteinuria; lupus nephritis; atypical hemolytic uremic syndrome (aHUS); COMPLEMENT INHIBITOR ECULIZUMAB; HEMOLYTIC-UREMIC SYNDROME; THROMBOCYTOPENIC PURPURA; ANTIPHOSPHOLIPID SYNDROME; TERMINAL COMPLEMENT; RECURRENCE; NEPHRITIS; PATIENT;

D O I：

10.1053/j.ajkd.2014.07.031

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombotic microangiopathy (TMA) is a severe disorder with poor outcomes. The cause is unknown for many patients, although TMA is associated with connective tissue disorders, including systemic lupus erythematosus (SLE). While uncommon, TMA is one of the most serious complications of SLE and in many cases may be resistant to therapy. We report a patient with SLE complicated by TMA that was refractory to standard therapy but responded well to eculizumab, with continued remission after 1 year of follow-up. Eculizumab might be useful in the management of resistant cases of TMA caused by SLE. (C) 2014 by the National Kidney Foundation, Inc.

引用

页码：127 / 130

页数：4

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