Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

被引：14

作者：

Jiang, Chunyu ^{[1
,2
]}

Yang, Mengyue ^{[1
,2
]}

Zhao, Chunxue ^{[1
,2
]}

Liu, Fangshen ^{[1
,2
]}

Yang, Hangao ^{[1
,2
]}

Li, Zhanlin ^{[1
,2
]}

Han, Tong ^{[3
]}

Lin, Bin ^{[1
,2
]}

Li, Dahong ^{[1
,2
]}

Hua, Huiming ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, 103 Wenhua Rd, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, 103 Wenhua Rd, Shenyang 110016, Peoples R China

[3] Heilongjiang Bayi Agr Univ, Coll Life Sci & Technol, Dept Pharmaceut Engn, 5 Xinfeng Rd, Daqing 163319, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 199卷

基金：

中国国家自然科学基金;

关键词：

Cephalotaxus oliveri Mast; Cephalotaxaceae; Abietane diterpenes; Antitumor activity; TRICYCLIC DITERPENOIDS; STEM BARK;

D O I：

10.1016/j.phytochem.2022.113187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 mu M and was further investigated for colony formation and apoptosis in HepG2 cells.

引用

页数：8

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