In vitro pharmacological activity of the tetrahydroisoquinoline salsolinol present in products from Theobroma cacao L. like cocoa and chocolate

被引：36
作者：
Melzig, MF
Putscher, I
Henklein, P
Haber, H
机构：
[1] Humboldt Univ, Inst Pharm, D-13086 Berlin, Germany
[2] Res Inst Mol Pharmacol, D-10315 Berlin, Germany
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 73卷 / 1-2期
关键词：
Theobroma cacao; chocolate; salsolinol; dopamine receptors; beta-endorphin; addiction;
D O I：
10.1016/S0378-8741(00)00291-9
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Cocoa and chocolate contain the tetrahydroisoquinoline alkaloid salsolinol up to a concentration of 25 mug/g. Salsolinol is a dopaminergic active compound which binds to the D-2 receptor family, especially to the D-3 receptor with a K-i of 0.48 +/- 0.021 mu mol/l. If inhibits the formation of cyclic AMP and the release of beta -endorphin and ACTH in a pituitary cell system. Taking the detected concentration and the pharmacological properties into account, salsolinol seems to be one of the main psychoactive compounds present in cocoa and chocolate and might be included in chocolate addiction. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：153 / 159
页数：7
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