Suppression of collagen-induced arthritis with histone H1

被引：0
作者：
Jung, N
Kim, DS
Kwon, HY
Yi, YW
Kim, D
Kang, AD
Cho, CH
Hong, SS
Lee, HS
Bae, I
机构：
[1] Samyang Genex Biotech Res Inst, Therapeut Gene Grp, Team 1, Taejon 305348, South Korea
[2] Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea
[3] Keimyung Univ, Sch Med, Dept Obstet & Gynecol, Taegu, South Korea
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2000年 / 29卷 / 04期
关键词：
collagen induced arthritis; histone H1; IL-10;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Besides roles in nucleus mediating the condensation of DNA into chromatin, the involvement of histones in autoimmune diseases, hormone regulation, and killing leukemia cells has been reported. In order to investigate the functions of histones on an autoimmune disease, histone H1 was injected into collagen-induced arthritis (CIA) mice. A dramatic suppression of CIA by histone H1 was observed at a dose of 1 mg/ kg bodyweight of mouse. In addition, the increased level of anti-inflammatory cytokine IL-10 was detected in cultured splenocytes from the mouse treated with histone H1. These findings suggest that histone H1 suppresses the collagen-induced arthritis, possibly by increasing the level of IL-10 production.
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收藏
页码：222 / 225
页数：4
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