Immunoglobulin G4-Related Sclerosing Cholangitis Revealed by 68Ga-FAPI PET/MR

被引：15
作者：
Qin, Chunxia [1 ,2 ]
Yang, Ling [3 ]
Ruan, Weiwei [1 ,2 ]
Shao, Fuqiang [1 ,2 ]
Lan, Xiaoli [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nucl Med, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Hubei Key Lab Mol Imaging, Wuhan, Peoples R China
[3] Huazhong Univ Sci & Technol, Div Gastroenterol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China
来源：
CLINICAL NUCLEAR MEDICINE | 2021年 / 46卷 / 05期
关键词：
F-18-FDG; Ga-68-FAPI; IgG4-related sclerosing cholangitis; PET/MR;
D O I：
10.1097/RLU.0000000000003552
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 60-year-old woman with surgically confirmed immunoglobulin G4-related sclerosing cholangitis underwent F-18-FDG PET/CT due to significantly elevated serum CA-19-9 level, which revealed a hypermetabolic lesion in the residual liver. Ga-68-FAPI PET/MR was performed to further evaluate whether the FDG-avid lesion is a malignant tumor. Astonishingly, diffuse intense radioactivity was revealed throughout the liver, suggesting involvement of active immunoglobulin G4-related sclerosing cholangitis, but nonfocal elevated Ga-68-FAPI accumulation in the FDG-avid lesion indicated postoperative change. From this case, we speculated that FAPI imaging could be used for evaluation of chronic liver disease because fibroblast activation protein has a profibrogenic role in chronic liver injury.
引用
收藏
页码：419 / 421
页数：3
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