Neural stem cell niche heterogeneity

被引：80

作者：

Andreotti, Julia P. ^{[1
]}

Silva, Walison N. ^{[1
]}

Costa, Alinne C. ^{[1
]}

Picoli, Caroline C. ^{[1
]}

Bitencourt, Flavia C. O. ^{[1
]}

Coimbra-Campos, Leda M. C. ^{[1
]}

Resende, Rodrigo R. ^{[2
]}

Magno, Luiz A. V. ^{[3
]}

Romano-Silva, Marco A. ^{[3
]}

Mintz, Akiva ^{[4
]}

Birbrair, Alexander ^{[1
,4
]}

机构：

[1] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Mental Hlth, Belo Horizonte, MG, Brazil

[4] Columbia Univ, Med Ctr, Dept Radiol, New York, NY USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2019年 / 95卷

关键词：

Neural stem cell; Niche; Microenvironment; Maintenance; Plasticity; SUBVENTRICULAR ZONE; CEREBROSPINAL-FLUID; VASCULAR NICHE; HIPPOCAMPAL NEUROGENESIS; OLFACTORY-BULB; CHOROID-PLEXUS; PROGENITOR CELLS; NEUROPEPTIDE-Y; PERICYTES PARTICIPATE; ADULT NEUROGENESIS;

D O I：

10.1016/j.semcdb.2019.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between neural stem cells and their niche components is essential for the development of therapies against neurological disorders in which neural stem cells function is altered. In this review, we describe and discuss recent studies that identified novel components in the neural stem cell niche. These discoveries bring new concepts to the field. Here, we evaluate these recent advances that change our understanding of the neural stem cell niche heterogeneity and its influence on neural stem cell function.

引用

页码：42 / 53

页数：12

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