Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of α-galactosidase

被引：23

作者：

Ganesan, Muthupandian ^{[1
]}

Madhukarrao, Rekhawar V. ^{[1
]}

Ramesh, Namakkal G. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 07期

关键词：

GLYCOSIDASE INHIBITORS; BETA-GLUCOSIDASE; DERIVATIVES; 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL; OSTEOARTHRITIS; AZASUGARS; DMDP; STRATEGY; GLYCALS; ANALOG;

D O I：

10.1039/b926123k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and short synthesis of hitherto unreported stereo analogue of amino-modified five-membered iminocyclitols from readily available tri-O-benzyl-D-glucal is described. Significantly, glycosidase inhibition studies of alkylamino substituted iminocyclitols display a high degree of selectivity towards alpha-galactosidase.

引用

页码：1527 / 1530

页数：4

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