Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of α-galactosidase

被引：23
|
作者：
Ganesan, Muthupandian [1 ]
Madhukarrao, Rekhawar V. [1 ]
Ramesh, Namakkal G. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 07期
关键词：
GLYCOSIDASE INHIBITORS; BETA-GLUCOSIDASE; DERIVATIVES; 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL; OSTEOARTHRITIS; AZASUGARS; DMDP; STRATEGY; GLYCALS; ANALOG;
D O I：
10.1039/b926123k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and short synthesis of hitherto unreported stereo analogue of amino-modified five-membered iminocyclitols from readily available tri-O-benzyl-D-glucal is described. Significantly, glycosidase inhibition studies of alkylamino substituted iminocyclitols display a high degree of selectivity towards alpha-galactosidase.
引用
收藏
页码：1527 / 1530
页数：4
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