A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus

被引：26
作者：
Elhady, Sameh S. [1 ,2 ]
El-Halawany, Ali M. [2 ,3 ]
Alahdal, Abdulrahman M. [4 ]
Hassanean, Hashim A. [1 ]
Ahmed, Safwat A. [1 ]
机构：
[1] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
[2] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21589, Saudi Arabia
[3] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Kasr el Aini St, Cairo 11562, Egypt
[4] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia
来源：
MOLECULES | 2016年 / 21卷 / 01期
关键词：
Red Sea sponge; Hyrtios erectus; 24-methoxypetrosaspongia C; scalarane sesterterpenes; cancer cell lines; growth inhibitory activity; SCALARIN-LIKE PYRROLOTERPENE; ANTINEOPLASTIC AGENTS; CACOSPONGIA-MOLLIOR; NATURAL-PRODUCTS; ALTOHYRTIN-A; CELL-LINES; SESTERTERPENES; FOLIASCENS; ALKALOIDS; MACROLIDE;
D O I：
10.3390/molecules21010082
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments. The isolated compounds showed growth inhibitory activity against hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT-116) and breast adenocarcinoma cells (MCF-7).
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页数：9
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