Enantioselective Friedel-Crafts Alkylation Reactions of 3-Substituted Indoles with Electron-Deficient Alkenes

被引：34

作者：

Weng, Jian-Quan ^{[1
]}

Fan, Ren-Jie ^{[1
]}

Deng, Qiao-Man ^{[1
]}

Liu, Ren-Rong ^{[1
]}

Gao, Jian-Rong ^{[1
]}

Jia, Yi-Xia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 07期

基金：

中国国家自然科学基金;

关键词：

4,7-DIHYDROINDOLES; CONSTRUCTION; ACCESS; ACIDS; CATALYSIS; CASCADE;

D O I：

10.1021/acs.joc.6b00123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles with alpha,beta-unsaturated esters and nitroalkenes were developed using chiral Lewis acids as catalysts, which afforded chiral indole derivatives bearing C2-benzylic stereogenic centers in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee).

引用

页码：3023 / 3030

页数：8

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