Autosomal single-gene disorders involved in human infertility

被引:17
|
作者
Jedidi, Ines [1 ]
Ouchari, Mouna [2 ]
Yin, Qinan [2 ,3 ]
机构
[1] Fac Med Sousse, Mohamed El Karoui St, Sousse 4002, Tunisia
[2] NIH, Ctr Clin, Bethesda, MD 20892 USA
[3] China Meitan Gen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
关键词
Human infertility; Single-gene mutation; Autosomal gene; Recessive; Dominant; GONADOTROPIN-RELEASING-HORMONE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; ENCODING STEROIDOGENIC FACTOR-1; SRY-RELATED GENE; SEX REVERSAL; CAMPOMELIC DYSPLASIA; HYPOGONADOTROPIC HYPOGONADISM; RECEPTOR GENE; WILMS-TUMOR; COMMON MUTATION;
D O I
10.1016/j.sjbs.2017.12.005
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human infertility, defined as the inability to conceive after 1 year of unprotected intercourse, is a healthcare problem that has a worldwide impact. Genetic causes of human infertility are manifold. In addition to the chromosomal aneuploidies and rearrangements, single-gene defects can interfere with human fertility. This paper provides a review of the most common autosomal recessive and autosomal dominant single-gene disorders involved in human infertility. The genes reviewed are CFTR, SPATA16, AURKC, CATSPER1, GNRHR, MTHFR, SYCP3, SOX9, WT1 and NR5A1 genes. These genes may be expressed throughout the hypothalamic-pituitary-gonadal-outflow tract axis, and the phenotype of affected individuals varies considerably from varying degrees of spermatogenic dysfunction leading to various degrees of reduced sperm parameters, through hypogonadotropic hypogonadism reslting in pubertal deficiencies, until gonadal dysgenesis and XY and XX sex reversal. Furthermore, congenital bilateral absence of the vas deferens, as well as premature ovarian failure, have been reported to be associated with some single-gene defects. (C) 2017 The Authors.
引用
收藏
页码:881 / 887
页数:7
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