New cucurbitane triterpenoids with cytotoxic activities from Hemsleya penxianensis

被引：19

作者：

Li, Pengfei ^{[1
]}

Zhu, Nailiang ^{[1
]}

Hu, Meigeng ^{[1
]}

Wu, Haifeng ^{[1
]}

Yu, Tian ^{[1
]}

Wu, Tongyu ^{[2
]}

Zhang, Dawei ^{[3
]}

Sun, Zhonghao ^{[1
]}

Yang, Junshan ^{[1
]}

Ma, Guoxu ^{[1
]}

Xu, Xudong ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev,Minist Educ, Key Lab Bioact Subst & Resource Utililizat Chines, Beijing 100193, Peoples R China

[2] Harbin Univ Commerce, Ctr Res & Dev Life Sci & Environm Sci, Harbin 150076, Heilongjiang, Peoples R China

[3] Jiangsu Univ Technol, Sch Elect & Informat Engn, Inst Bioinformat & Med Engn, Changzhou 213001, Peoples R China

来源：

FITOTERAPIA | 2017年 / 120卷

关键词：

Hemsleya penxianensis; Triterpenoids; Alkaloid; Cytotoxic activities; JINFUSHANENSIS; GLYCOSIDES; TUBERS; IIA;

D O I：

10.1016/j.fitote.2017.06.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new cucurbitane triterpenoids, Pengxianencins A-G (1-7) including one alkaloid, were isolated from the ethanol extract of the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic data, including 1D and 2D NMR spectra as well as HR-ESI-MS. The evaluation of inhibition activity against human Hela, MCF-7, and A-549 cell lines showed that compounds 1, 4, 6, 7 have different levels of cytotoxic activities, with IC50 values ranging from 1.67 to 45.28 mu M.

引用

页码：158 / 163

页数：6

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