RecQ4: the second replicative helicase?

被引：27

作者：

Capp, Christopher ^{[1
]}

Wu, Jianhong ^{[1
]}

Hsieh, Tao-shih ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 45卷 / 03期

关键词：

DNA replication; RecQ helicase; Sld2; Rothmund-Thomson syndrome; RAPADILINO; Baller-Gerold syndrome; ROTHMUND-THOMSON-SYNDROME; SYNDROME GENE-PRODUCT; DNA-REPLICATION; GENOTOXIC AGENTS; GENOME STABILITY; BUDDING YEAST; PROTEIN; INITIATION; MUTATIONS; COMPLEX;

D O I：

10.3109/10409231003786086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent work has greatly contributed to the understanding of the biology and biochemistry of RecQ4. It plays an essential non-enzymatic role in the formation of the CMG complex, and thus replication initiation, by means of its Sld2 homologous domain. The helicase domain of RecQ4 has now been demonstrated to possess 3'-5' DNA helicase activity, like the other members of the RecQ family. The biological purpose of this activity is still unclear, but helicase-dead mutants are unable to restore viability in the absence of wildtype RecQ4. This indicates that RecQ4 performs a second role, which requires helicase activity and is implicated in replication and DNA repair. Thus, it is clear that two helicases, RecQ4 and Mcm2-7, are integral to replication. The nature of the simultaneous involvement of these two helicases remains to be determined, and possible models will be proposed.

引用

页码：233 / 242

页数：10

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