The Effect of Anticoagulants on the Distribution of Chromium VI in Blood Fractions

被引：15

作者：

Afolaranmi, Grace A. ^{[2
]}

Tettey, Justice N. A. ^{[2
]}

Murray, Helen M. ^{[3
]}

Meek, R. M. Dominic ^{[3
]}

Grant, M. Helen ^{[1
]}

机构：

[1] Univ Strathclyde, Bioengn Unit, Wolfson Ctr, Glasgow G4 0NW, Lanark, Scotland

[2] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NW, Lanark, Scotland

[3] So Gen Hosp, Dept Orthopaed Surg, Glasgow G51 4TF, Lanark, Scotland

来源：

JOURNAL OF ARTHROPLASTY | 2010年 / 25卷 / 01期

关键词：

hexavalent chromium; orthopedic implants; distribution in blood; anticoagulant; plasma; red blood cells; HIP-ARTHROPLASTY; METAL LEVELS;

D O I：

10.1016/j.arth.2008.10.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Metal-on-metal resurfacing arthroplasty is associated with elevated circulating levels of cobalt and chromium ions. To establish the long-term safety of metal-on-metal resurfacing arthroplasty, it has been recommended that during clinical follow-up of these patients, the levels of these metal ions in blood be monitored. In this article, we provide information on the distribution of chromium VI ions (the predominant form of chromium released by cobalt-chrome alloys in vivo and in vitro) in blood fractions. Chromium VI is predominantly partitioned into red blood cells compared with plasma (analysis of variance, P < .05). The extent of accumulation in red blood cells is influenced by the anticoagulant used to collect the blood, with EDTA giving a lower partitioning into red cells compared with sodium citrate and sodium heparin.

引用

页码：118 / 120

页数：3

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