Science to Practice: Opening the Blood-Brain Barrier with Focused Ultrasound-A Potential Treatment for Alzheimer Disease?

被引：7
作者：
Jolesz, Ferenc A. [1 ]
机构：
[1] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
来源：
RADIOLOGY | 2014年 / 273卷 / 03期
关键词：
SURGERY;
D O I：
10.1148/radiol.14142033
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Burgess et al (1) present intriguing results of repetitive transient opening of the blood-brain barrier (BBB) in a transgenic mouse model of advanced Alzheimer disease (AD). The results underscore the potential of using magnetic resonance (MR) imaging-guided focused ultrasound and microbubble ultrasonography (US) contrast agents for the disruption of the BBB as a potential long-term therapy to reduce amyloid plaque burden and improve cognitive performance. This daring conclusion that is based on an experimental animal model should now be confirmed in humans. Considering that the technology is commercially available and given the immense clinical need, clinical trials in this AD treatment should be initiated as soon as possible.
引用
收藏
页码：631 / 633
页数：3
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