PH responsiveness of block copolymer vesicles with a polypeptide corona

被引：64

作者：

Sigel, Reinhard ^{[1
]}

Losik, Magdalena ^{[1
]}

Schlaad, Helmut ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces Colloid Che, D-14424 Potsdam, Germany

来源：

LANGMUIR | 2007年 / 23卷 / 13期

关键词：

D O I：

10.1021/la7004248

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aggregation behavior of polybutadiene(165)-block-poly(L-lysine)(88) in saline solution was studied by combined static and dynamic light scattering analyses. Vesicles were observed if the polypeptide segment was in a 100% coil conformation (pH 7.0) or in an 80% alpha-helical conformation (pH 10.3). At the higher pH, aggregates were smaller in size (hydrodynamic radius: 364 nm -> 215 nm) and chains were more densely packed at the core-corona interface (interchain distance: 3.2 nm -> 2.4 nm). Changes in size and structure could be explained in basic terms of colloid stabilization without considering a secondary structure effect.

引用

页码：7196 / 7199

页数：4

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