Accurate Prediction of Prognosis After Radical Resection of Gastric Cancer by the Modified Systemic Inflammation Score; a Multicenter Dataset Analysis

被引：10

作者：

Inagaki, Kota ^{[1
]}

Kanda, Mitsuro ^{[1
]}

Nakanishi, Koki ^{[1
]}

Ito, Seiji ^{[2
]}

Mochizuki, Yoshinari ^{[3
]}

Teramoto, Hitoshi ^{[4
]}

Ishigure, Kiyoshi ^{[5
]}

Murai, Toshifumi ^{[6
]}

Asada, Takahiro ^{[7
]}

Ishiyama, Akiharu ^{[8
]}

Matsushita, Hidenobu ^{[9
]}

Tanaka, Chie ^{[1
]}

Kobayashi, Daisuke ^{[1
]}

Fujiwara, Michitaka ^{[1
]}

Murotani, Kenta ^{[10
]}

Kodera, Yasuhiro ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Gastroenterol Surg Surg 2, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan

[2] Aichi Canc Ctr, Dept Gastroenterol Surg, Nagoya, Aichi, Japan

[3] Komaki City Hosp, Dept Surg, Komaki, Japan

[4] Yokkaichi Municipal Hosp, Dept Surg, Yokaichi, Japan

[5] Konan Kosei Hosp, Dept Surg, Konan, Japan

[6] Ichinomiya Municipal Hosp, Dept Surg, Ichinomiya, Japan

[7] Gifu Prefectural Tajimi Hosp, Dept Surg, Tajimi, Japan

[8] Okazaki City Hosp, Dept Surg, Okazaki, Aichi, Japan

[9] Tosei Gen Hosp, Dept Surg, Seto, Japan

[10] Kurume Univ, Biostat Ctr, Grad Sch Med, Kurume, Fukuoka, Japan

来源：

WORLD JOURNAL OF SURGERY | 2021年 / 45卷 / 08期

关键词：

SUPPLEMENTED ENTERAL NUTRITION; RANDOMIZED CLINICAL-TRIAL; SURVIVAL; RATIO;

D O I：

10.1007/s00268-021-06138-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background The presence of chronic inflammation and nutritional status in cancer patients affects its prognosis. There is a clinical need for a prognostic predictor that is objective and accurate, and that can be easily evaluated by preoperative screening. We evaluated the importance and usefulness of the preoperative modified systemic inflammation score (mSIS) to predict the long-term outcome of patients undergoing curative resection for gastric cancer (GC). Methods Of the 3571 patients who underwent curative resection for GC in nine institutions between January 2010 and December 2014, 1764 patients who met the inclusion criteria were included. The mSIS was formulated according to the serum albumin level (ALB) and lymphocyte-to-monocyte ratio (LMR) as follows: mSIS 0 (ALB >= 4.0 g/dL and LMR >= 3.4), mSIS 1 (ALB < 4.0 g/dL or LMR < 3.4), and mSIS 2 (ALB < 4.0 g/dL and LMR < 3.4). Results Patients were categorized into preoperative mSIS 0 (n = 955), mSIS 1 (n = 584), and mSIS 2 (n = 225) groups. The overall survival times and the disease-free survival times of patients in preoperative mSIS 0,1 and 2 sequentially shortened (P < 0.0001), and mSIS 1 and 2 were identified as an independent prognostic factor (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.06-1.272, P = 0.0125 and HR 1.63, 95% CI 1.21-2.19, P = 0.0012). A stepwise increase in the prevalence of hematogenous recurrences was directly proportional to the mSIS. A forest plot revealed that mSIS 0,1 was associated with a greater risk of overall survival in most subgroups. Conclusion Preoperative mSIS can be easily calculated, and it is suggested that it is useful as a prognostic predictor of patients with different disease stages, for stratifying and evaluating clinical outcomes.

引用

页码：2513 / 2520

页数：8

共 25 条

[1] The Lymphocyte-to-Monocyte Ratio is a Superior Predictor of Overall Survival in Comparison to Established Biomarkers of Resectable Colorectal Cancer [J].