Systemic Sclerosis Associated Interstitial Lung Disease: New Directions in Disease Management

被引：15

作者：

Mirsaeidi, Mehdi ^{[1
]}

Barletta, Pamela ^{[1
]}

Glassberg, Marilyn K. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Div Pulm Crit Care & Sleep Med, Miami, FL 33136 USA

来源：

FRONTIERS IN MEDICINE | 2019年 / 6卷

关键词：

scleroderma; interstitial lung disease; systemic sclerosis; cyclophosphamide; nintedanib; pirfenidone; STEM-CELL TRANSPLANTATION; EULAR SCLERODERMA TRIALS; PLACEBO-CONTROLLED TRIAL; PULMONARY-FUNCTION TESTS; GROWTH-FACTOR-BETA; PULSE CYCLOPHOSPHAMIDE; MYCOPHENOLATE-MOFETIL; DOUBLE-BLIND; RISK-FACTORS; OPEN-LABEL;

D O I：

10.3389/fmed.2019.00248

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A subgroup of patients with systemic sclerosis (SSc) develop interstitial lung disease (ILD), characterized by inflammation and progressive scarring of the lungs that can lead to respiratory failure. Although ILD remains the major cause of death in these individuals, there is no consensus statement regarding the classification and characterization of SSc-related ILD (SSc-ILD). Recent clinical trials address the treatment of SSc-ILD and the results may lead to new disease-altering therapies. In this review, we provide an update to the diagnosis, management and treatment of SSc-ILD.

引用

页数：10

共 90 条

[1] Ethnic Variations in Systemic Sclerosis Disease Manifestations, Internal Organ Involvement, and Mortality [J].

Al-Sheikh, Haifa ;

Ahmad, Zareen ;

Johnson, Sindhu R. .

JOURNAL OF RHEUMATOLOGY, 2019, 46 (09) :1103-1108

[2]

Laborde HA, 2012, GAC MED MEX, V148, P201

[3] Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers [J].

Barnes, Jammie ;

Mayes, Maureen D. .

CURRENT OPINION IN RHEUMATOLOGY, 2012, 24 (02) :165-170

[4] Survival of Adults With Systemic Sclerosis Following Lung Transplantation A Nationwide Cohort Study [J].

Bernstein, Elana J. ;

Peterson, Eric R. ;

Sell, Jessica L. ;

D'Ovidio, Frank ;

Arcasoy, Selim M. ;

Bathon, Joan M. ;

Lederer, David J. .

ARTHRITIS & RHEUMATOLOGY, 2015, 67 (05) :1314-1322

[5] Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma [J].

Bhattacharyya, Swati ;

Midwood, Kim S. ;

Yin, Hang ;

Varga, John .

ADVANCES IN WOUND CARE, 2017, 6 (10) :356-369

[6] Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses A Novel Mechanism for Maintaining and Amplifying Fibrosis in Scleroderma [J].

Bhattacharyya, Swati ;

Kelley, Kathleen ;

Melichian, Denisa S. ;

Tamaki, Zenshiro ;

Fang, Feng ;

Su, Yunyun ;

Feng, Gilbert ;

Pope, Richard M. ;

Budinger, G. R. Scott ;

Mutlu, Goekhan M. ;

Lafyatis, Robert ;

Radstake, Timothy ;

Feghali-Bostwick, Carol ;

Varga, John .

AMERICAN JOURNAL OF PATHOLOGY, 2013, 182 (01) :192-205

[7] Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome [J].

Bouros, D ;

Wells, AU ;

Nicholson, AG ;

Colby, TV ;

Polychronopoulos, V ;

Pantelidis, P ;

Haslam, PL ;

Vassilakis, DA ;

Black, CM ;

du Bois, RM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (12) :1581-1586

[8] Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial [J].

Burt, Richard K. ;

Shah, Sanjiv J. ;

Dill, Karin ;

Grant, Thomas ;

Gheorghiade, Mihai ;

Schroeder, James ;

Craig, Robert ;

Hirano, Ikuo ;

Marshall, Karin ;

Ruderman, Eric ;

Jovanovic, Borko ;

Milanetti, Francesca ;

Jain, Sandeep ;

Boyce, Kristin ;

Morgan, Amy ;

Carr, James ;

Barr, Walter .

LANCET, 2011, 378 (9790) :498-506

[9]

Cappelli S, 2015, EUR RESPIR REV, V24, P411, DOI 10.1183/16000617.00002915

[10] Cigarette Smoking Is Not a Risk Factor for Systemic Sclerosis [J].

Chaudhary, Prateek ;

Chen, Xing ;

Assassi, Shervin ;

Gorlova, Olga ;

Draeger, Hilda ;

Harper, Brock E. ;

Gonzalez, Emilio ;

McNearney, Terry ;

Perry, Marilyn ;

Arnett, Frank C. ;

Mayes, Maureen D. .

ARTHRITIS AND RHEUMATISM, 2011, 63 (10) :3098-3102

← 1 2 3 4 5 6 7 8 9 →