Systemic Sclerosis Associated Interstitial Lung Disease: New Directions in Disease Management

被引：15
作者：
Mirsaeidi, Mehdi [1 ]
Barletta, Pamela [1 ]
Glassberg, Marilyn K. [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Div Pulm Crit Care & Sleep Med, Miami, FL 33136 USA
来源：
FRONTIERS IN MEDICINE | 2019年 / 6卷
关键词：
scleroderma; interstitial lung disease; systemic sclerosis; cyclophosphamide; nintedanib; pirfenidone; STEM-CELL TRANSPLANTATION; EULAR SCLERODERMA TRIALS; PLACEBO-CONTROLLED TRIAL; PULMONARY-FUNCTION TESTS; GROWTH-FACTOR-BETA; PULSE CYCLOPHOSPHAMIDE; MYCOPHENOLATE-MOFETIL; DOUBLE-BLIND; RISK-FACTORS; OPEN-LABEL;
D O I：
10.3389/fmed.2019.00248
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A subgroup of patients with systemic sclerosis (SSc) develop interstitial lung disease (ILD), characterized by inflammation and progressive scarring of the lungs that can lead to respiratory failure. Although ILD remains the major cause of death in these individuals, there is no consensus statement regarding the classification and characterization of SSc-related ILD (SSc-ILD). Recent clinical trials address the treatment of SSc-ILD and the results may lead to new disease-altering therapies. In this review, we provide an update to the diagnosis, management and treatment of SSc-ILD.
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页数：10
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