Melanoma: the intersection of molecular targeted therapy and immune checkpoint inhibition

被引：19

作者：

Lau, Peter Kar Han ^{[1
]}

Ascierto, Paolo A. ^{[2
]}

McArthur, Grant ^{[1
]}

机构：

[1] Peter MacCallum Canc Ctr, Dept Canc Med, St Andrews Pl, East Melbourne, Vic 3002, Australia

[2] Fdn G Pascale, Ist Nazl Tumori, Melanoma Canc Immunotherapy & Innovat Therapy Uni, Via Mariano Semmola, I-80131 Naples, Italy

来源：

CURRENT OPINION IN IMMUNOLOGY | 2016年 / 39卷

关键词：

RANDOMIZED CONTROLLED-TRIAL; METASTATIC MELANOMA; BRAF INHIBITION; OPEN-LABEL; UNTREATED MELANOMA; SIGNALING PATHWAY; MUTANT MELANOMA; CANCER; VEMURAFENIB; RESISTANCE;

D O I：

10.1016/j.coi.2015.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Melanoma is at the forefront of development of systemic therapeutics with both molecular targeted therapies and immune checkpoint inhibitors as cornerstones of treatment. Although responses to molecularly targeted therapy is largely from blockade of oncogenic pathways, evidence is emerging of the immunomodulatory effects from BRAF inhibition. Additionally programmed-death-1 (PD-1) inhibitors have revolutionized the treatment of melanoma and are set to pave future improvements in other solid tumors. Combinations of PD-1 inhibitors with novel immune checkpoints or with molecularly targeted therapies are under investigation and may improve on the considerable progress made.

引用

页码：30 / 38

页数：9

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