ESTIMATION OF UNCERTAINTY FOR MEASURING CODEINE PHOSPHATE TABLETS FORMULATION USING UV-VIS SPECTROPHOTOMETRY

被引：6

作者：

Diaconu, Ioana ^{[2
]}

Aboul-Enein, Hassan Y. ^{[1
,3
]}

Bunaciu, Andrei A. ^{[4
]}

Tanase, Ion G. ^{[5
]}

机构：

[1] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Cairo 12311, Egypt

[2] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Analyt Chem & Instrumental Anal, Bucharest, Romania

[3] Univ Teknol Malaysia, Dept Chem, Fac Sci, Utm Skudai, Johor, Malaysia

[4] CROMATEC PLUS SRL, Analyt Res Dept, Bucharest, Romania

[5] Univ Bucharest, Fac Chem, Dept Analyt Chem, Bucharest, Romania

来源：

ANALYTICAL LETTERS | 2010年 / 43卷 / 7-8期

关键词：

Codeine analysis; Uncertainty estimation; UV-Vis spectrophotometry; Validation; ELECTROPHORESIS;

D O I：

10.1080/00032710903518633

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Analytical results represent a very important part in a quality control program. Uncertainty estimation is an important step in method validation. The objective of this paper is to study the uncertainty of measurement estimation in the quantitative determination of codeine phosphate from pharmaceutical formulations using UV-VIS spectrophotometry. The uncertainty estimation was performed using the Ishikawa diagram. The estimation of uncertainty components proved to be a good way for the experimental model to obtain low contribution of uncertainty to the analytical result.

引用

页码：1207 / 1216

页数：10

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