Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

被引：27
|
作者：
Shamim, Z. [1 ]
Muller, K.
Svejgaard, A.
Poulsen, L. K.
Bodtger, U.
Ryder, L. P.
机构：
[1] Rigshosp, Dept 7551, Paediat Clin 2, Copenhagen, Denmark
[2] Rigshosp, Dept 7551, Allergy Clin, Copenhagen, Denmark
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2007年 / 34卷 / 03期
关键词：
D O I：
10.1111/j.1744-313X.2007.00657.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7R alpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7R alpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
引用
收藏
页码：149 / 151
页数：3
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