Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery

被引：9

作者：

Ding, Guan-Jun ^{[1
]}

Zhu, Ying-Jie ^{[1
]}

Cheng, Guo-Feng ^{[1
]}

Ruan, Yin-Jie ^{[1
]}

Qi, Chao ^{[1
]}

Lu, Bing-Qiang ^{[1
]}

Chen, Feng ^{[1
]}

Wu, Jin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

CURRENT NANOSCIENCE | 2016年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Amorphous materials; calcium phosphate; casein; drug delivery; nanocomposite; nanostructures; ASSISTED HYDROTHERMAL SYNTHESIS; CASEIN PHOSPHOPEPTIDES; HYDROXYAPATITE; PROTEIN; SYSTEMS; FLUTAMIDE; MICELLES; RELEASE; NUTRACEUTICALS; NANOPARTICLES;

D O I：

10.2174/1573413711666150730204449

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Porous microspheres of casein/amorphous calcium phosphate nanocomposite are prepared using casein sodium salt, CaCl2, Na2HPO4 center dot 12H(2)O and NaH2PO4 center dot 2H(2)O in aqueous solution at room temperature. The effects of experimental parameters such as solution pH, casein sodium salt and ageing time on the product are investigated. Porous microspheres of casein/amorphous calcium phosphate nanocomposite are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and Brunauer-Emmett-Teller (BET) specific surface area and pore size distribution. The as-prepared porous microspheres of casein/amorphous calcium phosphate nanocomposite are favorable for drug loading and release using ibuprofen (IBU), docetaxel (Dtxl) and vitamin B5 (B5) as typical drugs, and show low cytotoxicity in the cytotoxicity test. Thus, porous microspheres of casein/amorphous calcium phosphate nanocomposite have promising applications in various biomedical fields such as drug delivery.

引用

页码：70 / 78

页数：9

共 39 条

[1] Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices [J].

Andersson, J ;

Rosenholm, J ;

Areva, S ;

Lindén, M .

CHEMISTRY OF MATERIALS, 2004, 16 (21) :4160-4167

[2]

[Anonymous], 2004, INFRARED SPECTROSCOP, DOI [10.1002/0470011149, DOI 10.1002/0470011149]

[3] Thermal degradation of edible films based on milk proteins and gelatin in inert atmosphere [J].

Barreto, PLM ;

Pires, ATN ;

Soldi, V .

POLYMER DEGRADATION AND STABILITY, 2003, 79 (01) :147-152

[4] Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug [J].

Cao, Shao-Wen ;

Zhu, Ying-Jie ;

Wu, Jin ;

Wang, Ke-Wei ;

Tang, Qi-Li .

NANOSCALE RESEARCH LETTERS, 2010, 5 (04) :781-785

[5] Multifunctional Calcium Phosphate Nanostructured Materials and Biomedical Applications [J].

Chen, Feng ;

Zhu, Ying-Jie .

CURRENT NANOSCIENCE, 2014, 10 (04) :465-485

[6] Multifunctional Eu3+/Gd3+ dual-doped calcium phosphate vesicle-like nanospheres for sustained drug release and imaging [J].

Chen, Feng ;

Huang, Peng ;

Zhu, Ying-Jie ;

Wu, Jin ;

Cui, Da-Xiang .

BIOMATERIALS, 2012, 33 (27) :6447-6455

[7] Food protein-based materials as nutraceutical delivery systems [J].

Chen, LY ;

Remondetto, GE ;

Subirade, M .

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2006, 17 (05) :272-283

[8]

Cochrane N J, 2012, Adv Dent Res, V24, P41, DOI 10.1177/0022034512454294

[9] Casein phosphopeptides in oral health - Chemistry and clinical applications [J].

Cross, K. J. ;

Huq, N. L. ;

Reynolds, E. C. .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (08) :793-800

[10] Yolk-Shell Porous Microspheres of Calcium Phosphate Prepared by Using Calcium L-Lactate and Adenosine 5′-Triphosphate Disodium Salt: Application in Protein/Drug Delivery [J].

Ding, Guan-Jun ;

Zhu, Ying-Jie ;

Qi, Chao ;

Sun, Tuan-Wei ;

Wu, Jin ;

Chen, Feng .

CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (27) :9868-9876

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