Initiation of angiogenic Kaposi's sarcoma lesions

被引：64
作者：
Hayward, GS [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Sydney Kimmel Oncol Ctr, Viral Oncol Program, Baltimore, MD 21231 USA
来源：
CANCER CELL | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1535-6108(03)00002-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Anew mouse model reported in this issue of Cancer Cell implies that VEGF/KDR-mediated paracrine effects induced by the lytic cycle vGPCR signaling protein encoded by human Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) may be involved in promoting the proliferation of the KSHV latently infected spindle endothelial cells of Kaposi's sarcoma.
引用
收藏
页码：1 / 3
页数：3
相关论文
共 12 条
  • [1] G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
    Bais, C
    Santomasso, B
    Coso, O
    Arvanitakis, L
    Raaka, EG
    Gutkind, JS
    Asch, AS
    Cesarman, E
    Gerhengorn, MC
    Mesri, EA
    [J]. NATURE, 1998, 391 (6662) : 86 - 89
  • [2] The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells
    Cannon, M
    Philpott, NJ
    Cesarman, E
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (01) : 57 - 67
  • [3] IDENTIFICATION OF HERPESVIRUS-LIKE DNA-SEQUENCES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA
    CHANG, Y
    CESARMAN, E
    PESSIN, MS
    LEE, F
    CULPEPPER, J
    KNOWLES, DM
    MOORE, PS
    [J]. SCIENCE, 1994, 266 (5192) : 1865 - 1869
  • [4] Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus
    Chiou, CJ
    Poole, LJ
    Kim, PS
    Ciufo, DM
    Cannon, JS
    ap Rhys, CM
    Alcendor, DJ
    Zong, JC
    Ambinder, RF
    Hayward, GS
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (07) : 3421 - 3439
  • [5] Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: Formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures
    Ciufo, DM
    Cannon, JS
    Poole, LJ
    Wu, FY
    Murray, P
    Ambinder, RF
    Hayward, GS
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (12) : 5614 - 5626
  • [6] Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma
    Dupin, N
    Fisher, C
    Kellam, P
    Ariad, S
    Tulliez, M
    Franck, N
    van Marck, E
    Salmon, D
    Gorin, I
    Escande, JP
    Weiss, RA
    Alitalo, K
    Boshoff, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) : 4546 - 4551
  • [7] Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture
    Gershengorn, MC
    Geras-Raaka, E
    Varma, A
    Clark-Lewis, I
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (08) : 1469 - 1472
  • [8] The molecular pathology of Kaposi's sarcoma-associated herpesvirus
    Jenner, RG
    Boshoff, C
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2002, 1602 (01): : 1 - 22
  • [9] Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: Implications for KS pathogenesis
    Kirshner, JR
    Staskus, K
    Haase, A
    Lagunoff, M
    Ganem, D
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (07) : 6006 - 6014
  • [10] Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes
    Montaner, S
    Sodhi, A
    Molinolo, A
    Bugge, TH
    Sawai, ET
    He, YS
    Li, Y
    Ray, PE
    Gutkind, JS
    [J]. CANCER CELL, 2003, 3 (01) : 23 - 36
12