HISTONE DEACETYLASE INHIBITOR CG200745 ATTENUATES CARDIAC HYPERTROPHY AND FIBROSIS IN DOCA-INDUCED HYPERTENSIVE RATS

被引：0
|
作者：
Kim, InKyeom [1 ]
Lee, Eunjo [1 ]
Song, Min-ji [1 ]
Lee, Do Young [2 ]
Ro, Seonggu [2 ]
Cho, Joong Myung [2 ]
机构：
[1] Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea
[2] CrystalGen Inc, Translat Res Ctr, Seongnam, South Korea
来源：
JOURNAL OF HYPERTENSION | 2016年 / 34卷
关键词：
D O I：
10.1097/01.hjh.0000501251.73468.de
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
PS 16-18
引用
收藏
页码：E470 / E470
页数：1
相关论文
共 50 条
  • [11] Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production
    Ga-Eun Yoon
    Jin Ki Jung
    Yun-Han Lee
    Byeong-Churl Jang
    Jee In Kim
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393 : 491 - 500
  • [12] Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production
    Yoon, Ga-Eun
    Jung, Jin Ki
    Lee, Yun-Han
    Jang, Byeong-Churl
    Kim, Jee In
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2020, 393 (03) : 491 - 500
  • [13] Preclinical studies of CG200745, novel histone deacetylase inhibitor discovered using structure-based drug discovery technologies
    Hyun, Young-Lan
    Kim, Hyun Ji
    Kim, Yong Eun
    Lee, Jun Hee
    Lee, Cheol Hae
    Jung, Hee Jung
    Kim, Jae Hak
    Choi, Eunha
    Shin, Dong-Kyu
    Park, Myung Guan
    Kim, Sun Nam
    Chang, Ho-Jin
    Choi, Jong-Ryoo
    Cho, Joong Myung
    Ro, Seonggu
    CANCER RESEARCH, 2009, 69
  • [14] Comparison of anticancer effects of a novel histone deacetylase (HDAC) inhibitor CG200745 and SAHA in non-small lung cancer cells
    Kim, Hak-Ryul
    Jung, Jae-Wan
    Hwang, Ki-Eun
    Park, Chul
    Jeong, Eun-Taik
    EUROPEAN RESPIRATORY JOURNAL, 2019, 54
  • [15] Phase I clinical, pharmacokinetic, and pharmacodynamic study of CG200745, a histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumors.
    Kim, Kyu-Pyo
    Hong, Yong Sang
    Ahn, Jin-Hee
    Lee, Jae-Lyun
    Bae, Kyun-Seop
    Kim, Tae Won
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [16] Anti-leukemic activity of a novel histone deacetylase inhibitor, CG200745, via induction of mitochondrial dysfunction in acute myeloid leukemia
    Hur, Eun-hye
    Goo, Bon-Kwan
    Kim, Sung-Doo
    Kim, Minhee
    Choi, Yunsuk
    Lee, Kyoo-Hyung
    Lee, Jung-Hee
    Kim, Dae-Young
    Hwang, Jung Jin
    Kim, Choung-Soo
    Ro, Seonggu
    Lee, Je-Hwan
    CANCER RESEARCH, 2012, 72
  • [17] Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells
    Eun-Taex Oh
    Moon-Taek Park
    Bo-Hwa Choi
    Seonggu Ro
    Eun-Kyung Choi
    Seong-Yun Jeong
    Heon Joo Park
    Investigational New Drugs, 2012, 30 : 435 - 442
  • [18] Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells
    Oh, Eun-Taex
    Park, Moon-Taek
    Choi, Bo-Hwa
    Ro, Seonggu
    Choi, Eun-Kyung
    Jeong, Seong-Yun
    Park, Heon Joo
    INVESTIGATIONAL NEW DRUGS, 2012, 30 (02) : 435 - 442
  • [19] A multiple ascending dose phase I clinical, pharmacokinetic, and pharmacodynamic study of CG200745, a histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumors
    Park, S. J.
    Kim, J. E.
    Kim, K. P.
    Hong, Y. S.
    Lee, J. L.
    Bae, K. S.
    Lee, J. S.
    Choi, E. K.
    Kim, T. W.
    EUROPEAN JOURNAL OF CANCER, 2013, 49 : S186 - S186
  • [20] A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL
    Jung Jin Hwang
    Yong Sook Kim
    Taelim Kim
    Mi Joung Kim
    In Gab Jeong
    Je-Hwan Lee
    Jene Choi
    Sejin Jang
    Seonggu Ro
    Choung-Soo Kim
    Investigational New Drugs, 2012, 30 : 1434 - 1442
12345