A facile method for Rh-catalyzed decarbonylative ortho-C-H alkylation of (hetero)arenes with alkyl carboxylic acids

被引：1
|
作者：
Tian, Yiqiang [1 ,2 ]
Liu, Xiaojie [1 ,2 ]
He, Bangyue [2 ]
Ren, Yuxi [2 ]
Su, Weiping [2 ]
机构：
[1] Fuzhou Univ, Coll Chem, Fuzhou 350116, Peoples R China
[2] Chinese Acad Sci, State Key Lab Struct Chem, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China
来源：
RSC ADVANCES | 2021年 / 11卷 / 32期
基金：
中国国家自然科学基金;
关键词：
TRANSIENT DIRECTING GROUPS; BOND FORMATION; POSSIBLE GENERATION; AROMATIC AMIDES; FUNCTIONALIZATION; DECARBOXYLATION; CARBOXAMIDES; ACTIVATION; PHOTOREDOX; HALIDES;
D O I：
10.1039/d1ra03992j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile and effective method for Rh-catalyzed direct ortho-alkylation of C-H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.
引用
收藏
页码：19827 / 19831
页数：5
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