Targeting Central Nervous System Regeneration with Cell Type Specificity

被引:8
作者
Anderson, Mark A. [1 ,2 ,3 ,4 ]
机构
[1] Ecole Polytech Fed Lausanne EPFL, Brain Mind Inst, Fac Life Sci, Lausanne, Switzerland
[2] Lausanne Univ Hosp CHUV, Dept Clin Neurosci, Neural Repair Unit, NeuroRestore, Lausanne, Switzerland
[3] Univ Lausanne UNIL, Lausanne, Switzerland
[4] Campus Biotech,Chemin Mines 9, CH-1202 Geneva, Switzerland
基金
瑞士国家科学基金会;
关键词
Spinal cord injury; Neuronal regeneration; Neural repair; Growth programs; RETINAL GANGLION-CELLS; SPINAL-CORD-INJURY; NEUROTROPHIC FACTOR PREVENTS; NEURAL STEM-CELLS; AXON REGENERATION; SCAR FORMATION; FIBROTIC SCAR; OPTIC-NERVE; ADULT CNS; CORTICOSPINAL NEURONS;
D O I
10.1016/j.nec.2021.03.011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is now compelling evidence suggesting that different neuronal subtypes display heterogeneous regenerative responses and possess specific activation requirements. Although the level of regeneration currently achievable is impressive, it fails to yield robust functional recovery. Given what is known about cellular heterogeneity, current strategies are likely biased to cell types with a particular transcriptomic profile. More information on growth programs within specific neuronal populations is required to overcome this barrier to growth. Going forward, it will be useful to develop a deeper and more nuanced understanding of the genetic and functional diversity that exists within the numerous populations of CNS neurons. This will enable researchers to create tailored and cell type-specific regenerative interventions that have the potential to restore functions lost through SCI.
引用
收藏
页码:397 / 405
页数:9
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