Adverse Drug Reactions in Paediatric In-Patients in a South African Tertiary Hospital

被引：7

作者：

Makiwane, Memela ^{[1
]}

Decloedt, Eric ^{[1
]}

Chirehwa, Maxwell ^{[2
]}

Rosenkranz, Bernd ^{[1
]}

Kruger, Mariana ^{[3
]}

机构：

[1] Stellenbosch Univ, Dept Med, Div Clin Pharmacol, ZA-8000 Cape Town, South Africa

[2] Stellenbosch Univ, Div Epidemiol & Biostat, ZA-8000 Cape Town, South Africa

[3] Stellenbosch Univ, Dept Paediat & Child Hlth, POB 241, ZA-8000 Cape Town, South Africa

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2019年 / 65卷 / 04期

关键词：

adverse drug reactions; prevalence; paediatric; in-patient; tertiary hospital; South Africa; CHILDREN;

D O I：

10.1093/tropej/fmy067

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: The prevalence of adverse drug reaction (ADR) rates in children in sub-Saharan Africa is unknown. Objectives: To describe the prevalence of ADRs in paediatric in-patients at a tertiary hospital in South Africa. Methods: This is a prospective study during a 3-month study period. Data collected included age, sex, diagnosis, medicines received and ADRs experienced. Causality were assessed, using the 10-question Naranjo probability scale and classified according to the Hartwig severity scale. Results: There were 61 ADRs in 18.4% (52 of 282) of patients. Median age of patients was 1.4 years (interquartile range: 0.5-5.3 years). ADR was the primary admission reason in 31%. The majority of the ADRs were moderate 45.9% (28 of 61), and only 11.5% severe (7 of 61). Paediatric oncology patients suffered significantly more ADRs (56.5%; 13 of 23) [odds ratio 7.3 (3.0-17.9), p<0.01], followed by HIV-infected patients (42.9%; 9 of 21). Conclusion: The prevalence of ADRs was 18.4%, while 31% was the reason for admission.

引用

页码：389 / 396

页数：8

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