The role of small leucine-rich proteoglycans in collagen fibrillogenesis

被引：334
作者：
Kalamajski, Sebastian [1 ]
Oldberg, Ake [1 ]
机构：
[1] Lund Univ, Dept Expt Med Sci, Lund, Sweden
来源：
MATRIX BIOLOGY | 2010年 / 29卷 / 04期
关键词：
SLRP; Proteoglycan; Collagen; Fibrillogenesis; Extracellular matrix; PYRIDINOLINE CROSS-LINKS; EXTRACELLULAR-MATRIX; REPEAT PROTEINS; I COLLAGEN; DECORIN; BIGLYCAN; FIBROMODULIN; LUMICAN; FIBRILS; BINDING;
D O I：
10.1016/j.matbio.2010.01.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril formation, and therefore important for the proper formation of extracellular matrices. SLRPs are differentially expressed in tissues and during pathological conditions, contributing to the development of connective tissue properties. The binding of SLRPs to collagens have recently been characterized, and may give some clues to the significance of these interactions. In this mini review, we summarize published work in this field, and propose several mechanisms for how SLRPs can control collagen matrix structure and function. SLRPs appear to influence collagen cross-linking patterns. We also propose that the SLRP-collagen interactions can assist in the process of juxtaposing the collagen monomers by steric hindrance or by directly connecting two collagen monomers during the fibril growth. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：248 / 253
页数：6
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