cis-DECODER discovers constellations of conserved DNA sequences shared among tissue-specific enhancers

被引：19
作者：
Brody, Thomas
Rasband, Wayne
Baler, Kevin
Kuzin, Alexander
Kundu, Mukta
Odenwald, Ward F.
机构：
[1] NINDS, Neural Cell Fate Determinant Sect, NIH, Bethesda, MD 20892 USA
[2] NIMH, Off Sci Directorate, IRP, NIH, Bethesda, MD 20892 USA
来源：
GENOME BIOLOGY | 2007年 / 8卷 / 05期
关键词：
comparative genomics; evolution; enhancer structure and function;
D O I：
10.1186/gb-2007-8-5-r75
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A systematic approach is described for analysis of evolutionarily conserved cis-regulatory DNA using cis-Decoder, a tool for discovery of conserved sequence elements that are shared between similarly regulated enhancers. Analysis of 2,086 conserved sequence blocks ( CSBs), identified from 135 characterized enhancers, reveals most CSBs consist of shorter overlapping/adjacent elements that are either enhancer type-specific or common to enhancers with divergent regulatory behaviors. Our findings suggest that enhancers employ overlapping repertoires of highly conserved core elements.
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页数：52
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