Engineering Metal-Organic Framework-based Nanozymes for Enhanced Biosensing

被引：7

作者：

Xu, Weiqing ^{[1
]}

Wu, Yu ^{[1
]}

Jiao, Lei ^{[1
]}

Gu, Wenling ^{[1
]}

Du, Dan ^{[2
]}

Lin, Yuehe ^{[2
]}

Zhu, Chengzhou ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr ForIntelligent Biosensing Techn, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China

[2] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA

来源：

CURRENT ANALYTICAL CHEMISTRY | 2022年 / 18卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Metal-organic frameworks; nanozymes; biosensing; colorimetry; fluorescence; electrochemistry; PEROXIDASE-LIKE ACTIVITY; SINGLE-ATOM NANOZYME; COLORIMETRIC DETECTION; SIGNAL AMPLIFICATION; SUPEROXIDE-DISMUTASE; MIMICKING ACTIVITIES; SENSITIVE DETECTION; GOLD NANOPARTICLES; CATALYTIC-ACTIVITY; HYDROGEN-PEROXIDE;

D O I：

10.2174/1573411017666210824115722

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Background: Nanozymes are a kind of emerging nanomaterials that can mimic the catalytic activity of natural enzymes with good stability. Objective: Benefited by the unique coordination structure and constitution, metal-organic frameworks (MOFs) have been widely exploited as novel nanozymes. Importantly, various MOFs engineered with fascinating functions provide great opportunities to enhance their enzyme-like activity and improve their applied performance, achieving the goal of vividly mimicking natural enzymes. Conclusion: This review summarized recent advances in the fabrication of the MOFs-based nanozymes and their applications in biosensing. First, MOFs-based nanomaterials containing pristine MOFs, functionalized MOFs, MOFs-based composites and MOFs derivatives are introduced, where the design strategy, enzyme-like activity and the catalytic mechanisms are highlighted systematically. Then, their applications in various target assays are summarized. Finally, the challenges and possible research directions for the development and application of MOFs-based nanozymes are provided.

引用

页码：739 / 752

页数：14

共 78 条

[1] MIL-53(Fe): A Metal-Organic Framework with Intrinsic Peroxidase-Like Catalytic Activity for Colorimetric Biosensing [J].