Gypenoside LXXIV Ameliorates Scopolamine-Induced Learning Deficit in Mice

被引：13

作者：

Joh, Eun-Ha

Yang, Jeong-Wha

Kim, Dong-Hyun ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Pharmaceut Sci, Seoul 130701, South Korea

来源：

PLANTA MEDICA | 2010年 / 76卷 / 08期

关键词：

Gynostemma pentaphyllum; Cucurbitaceae; gypenoside LXXIV; learning; memory; scopolamine; GINSENOSIDES; SAPONINS; DISEASE; INJURY;

D O I：

10.1055/s-0029-1240795

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Gypenoside LXXIV (G-74), a major constituent of Gynostemma pentaphyllum Makino (GP; family Cucurbitaceae), was isolated and its memory-enhancing effects were investigated in scopolamine-treated mice in passive-avoidance and Morris water maze tests. G-74 potently reversed memory impairment caused by scopolamine. G-74 also significantly shortened the scopolamine-prolonged escape latencies in the Morris water maze test (p < 0.05) and increased the scopolamine-shortened swimming time within the platform quadrant (p < 0.05). Based on these findings, G-74 might improve learning deficits.

引用

页码：793 / 795

页数：3

共 17 条

[1] Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging [J].