Melting point-solubility-structure correlations in multicomponent crystals containing fumaric or adipic acid

被引：49

作者：

Batisai, Eustina ^{[1
]}

Ayamine, Alban ^{[1
]}

Kilinkissa, Ornella E. Y. ^{[1
]}

Bathori, Nikoletta B. ^{[1
]}

机构：

[1] Cape Peninsula Univ Technol, Dept Chem, Crystal Engn Res Unit, ZA-8000 Cape Town, South Africa

来源：

CRYSTENGCOMM | 2014年 / 16卷 / 43期

基金：

新加坡国家研究基金会;

关键词：

X-RAY-DIFFRACTION; PHARMACEUTICAL CO-CRYSTALS; AQUEOUS SOLUBILITY; ORGANIC-COMPOUNDS; DRUG SOLUBILITY; COCRYSTALS; PREDICTION; ADDUCTS; WATER; SALT;

D O I：

10.1039/c4ce01298d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study investigates the relationships between the supramolecular structure and the solubility and melting point of six multicomponent crystals involving fumaric acid (FUM series) and adipic acid (ADI series). The crystals were prepared by solvent evaporation and fully characterised by thermal and diffraction techniques. In each series the melting points of the multicomponent crystals are lower than the relevant carboxylic acid and they show partial correlation with their aqueous solubilities. With the aid of Hirshfeld surface analysis, the relationships between solubility, melting point and the supramolecular structure are discussed.

引用

页码：9992 / 9998

页数：7