An Improved H-Phosphonate Approach for Practical Synthesis of Phosphoramidon

被引：0

作者：

Sun, Qi ^{[1
,2
]}

Yang, Qingkun ^{[1
]}

Gong, Shanshan ^{[1
]}

Sun, Jian ^{[1
]}

Li, Xingjian ^{[1
]}

Liu, Guodong ^{[2
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Jiangxi, Peoples R China

[2] Jiangxi Prov Coll & Univ, High Level Engn Res Ctr Biopharmaceut Mol & Diagn, Nanchang 330013, Jiangxi, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 12期

基金：

中国国家自然科学基金;

关键词：

oxidative coupling; phosphoramidate; inhibitor constant; Phosphoramidon; H-phosphonate; TRANSITION-STATE; THERMOLYSIN; INHIBITOR; BINDING; ANALOGS; STRATEGY;

D O I：

10.1080/10426507.2014.902829

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An improved synthetic method based on glycosyl-1-H-phosphonate monoester intermediate has been developed for the multigram-scale preparation of phosphoramidon, a naturally occurring phosphorus-linked glycodipeptide. The inhibitor constant of the synthetic sample against thermolysin established that a high level of biological activity can be obtained following this synthetic method.

引用

页码：1887 / 1894

页数：8

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