Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy

被引：85
作者：
Cao, Ziyang [1 ,2 ,3 ,4 ]
Li, Dongdong [1 ,2 ,3 ,4 ]
Wang, Junxia [1 ,2 ,3 ,4 ]
Yang, Xianzhu [1 ,5 ,6 ]
机构：
[1] South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Biomed Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China
[2] South China Univ Technol, Key Lab Biomed Mat & Engn, Minist Educ, Guangzhou 510006, Peoples R China
[3] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Peoples R China
[4] South China Univ Technol, Innovat Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
[5] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Guangdong, Peoples R China
[6] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Guangdong, Peoples R China
来源：
ACTA BIOMATERIALIA | 2021年 / 130卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
ROS-sensitive nanocarriers; ROS-responsive polymer; Drug delivery; Synergistic cancer therapy; PHOTODYNAMIC THERAPY; ANTICANCER DRUG; RESPONSIVE NANOPARTICLES; HYALURONIC-ACID; ROS; MICELLES; DELIVERY; PHOTOSENSITIZER; CHEMOTHERAPY; RELEASE;
D O I：
10.1016/j.actbio.2021.05.023
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest in recent years. On the one hand, a high ROS level has been detected in many types of tumor cells. On the other hand, ROS generation is also induced during photodynamic, sonodynamic, or chemodynamic therapy. In addition, multiple types of polymers are sensitive to ROS. Therefore, numerous ROS-responsive polymeric nanocarriers with unique ROS-responsive characteristics have been developed. This review discusses ROSsensitive polymeric nanocarriers to improve drug delivery efficacy. In particular, ROS-responsive nanocarriers for synergistic cancer therapy are highlighted. The development of novel ROS-sensitive nanocarriers holds great potential for combining ROS-mediated therapy, such as photodynamic therapy, and other therapies to achieve synergistic anticancer efficacy. Statement of significance Reactive oxygen species (ROS)-responsive nanocarriers aroused widespread interest in recent years. On the one hand, a high level of ROS has been found in many types of tumor cells. On the other hand, the ROS generation can also be induced during the photodynamic, sonodynamic, or chemodynamic therapy. Besides, multiple types of polymers were sensitive to the ROS. Therefore, numerous ROS-responsive polymeric nanocarriers with unique ROS responsive characteristics have been developed. This review focuses on the ROS-sensitive polymeric nanocarriers to improve drug delivery efficacy for synergistic cancer therapy. (c) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：17 / 31
页数：15
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